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  • Title: Antibodies to BK virus in children prior to allogeneic hematopoietic cell transplant.
    Author: Laskin BL, Sullivan KE, Hester J, Goebel J, Davies SM, Jodele S.
    Journal: Pediatr Blood Cancer; 2015 Sep; 62(9):1670-3. PubMed ID: 25833296.
    Abstract:
    BK virus (BKV) is associated with kidney and bladder disease after hematopoietic cell transplantation (HCT) but less is known about the seroprevalence of pre-transplant antibodies to BKV in children. We measured BKV IgG antibody titers in 36 children before HCT. BKV IgG antibodies were detected in all 36 patients, with 28/36 (77.8%) developing BK viremia in the first 100 days. Pre-HCT BKV IgG antibody titers >1:40,960 were protective against later BK viremia ≥10,000 copies/ml. The seroprevalence of antibodies to BKV is high in children undergoing HCT and post-transplant BK viremia, which is associated with bladder and kidney injury, is common.
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