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  • Title: Three Polymorphisms of Vascular Endothelial Growth Factor (+936C > T, -460C > T, and -2578C > A) and Their Susceptibility to Ovarian Cancer: A Meta-Analysis.
    Author: Zhang X, Qin J, Qin A.
    Journal: Int J Gynecol Cancer; 2015 Jun; 25(5):779-85. PubMed ID: 25835351.
    Abstract:
    OBJECTIVE: Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen that plays a vital role in angiogenesis, tumor growth, and metastasis. The associations between 3 polymorphisms of VEGF (+936 C > T, -2578 C > A, and -460 C > T) and ovarian cancer (OC) risk have been extensively investigated, but the currently available results are inconsistent. To obtain a more accurate estimation of the association, a meta-analysis was conducted in this study. METHODS: PubMed, Cochrane Library, Embase, and Chinese National Knowledge Infrastructure were searched for all relevant studies published before November 30, 2014. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for the VEGF polymorphisms to assess the strength of the association. RESULTS: With regard to the +936 C > T polymorphism, 5 articles were available for analysis (882 cases and 1155 controls), whereas for -2578 C > A (559 cases and 632 controls) and -460 C > T (350 cases and 409 controls), only 2 articles were eligible for analysis, respectively. A significant association between the VEGF +936 C/T polymorphism and OC was demonstrated in white populations (CT vs CC: OR, 0.638 [95% CI, 0.437-0.932; P = 0.020]; TT + CT vs CC: OR, 0.694 [95% CI, 0.483-0.995; P = 0.047]). No relationship was found between -2578 C > A and -460 C > T and susceptibility to develop OC. CONCLUSIONS: This meta-analysis provides supportive evidence that the VEGF +936 C/T polymorphism may influence the risk for the development of OC in a protective model among whites.
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