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  • Title: Platelet serotonergic mechanisms and glomerulonephritis.
    Author: Mitra MK, Jain AK, Misra R, Sethi PP, Shukla RN, Chandra M, Verma M, Saxena AK, Shanker K.
    Journal: Indian J Exp Biol; 1989 Jun; 27(6):545-7. PubMed ID: 2583744.
    Abstract:
    Proven cases (28) of glomerulonephritis (GN) were evaluated for clinico-biochemical profile, bleeding time, platelet count, platelet aggregation and platelet serotonergic mechanisms. Inordinate increase in platelet aggregation and altered platelet serotonergic mechanisms (reduced 5-HT, uptake, reduced intraplatelet 5-HT and increased plasma 5-HT) were demonstrated in some histopathological types of GN. The mechanisms and importance of these alterations have been discussed.
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