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  • Title: Colorectal neoplasia pathways: state of the art.
    Author: IJspeert JE, Medema JP, Dekker E.
    Journal: Gastrointest Endosc Clin N Am; 2015 Apr; 25(2):169-82. PubMed ID: 25839680.
    Abstract:
    Colorectal cancer (CRC) is a heterogeneous disease and each CRC possesses a unique molecular tumor profile. The main pathways of oncogenesis are the chromosomal instability, microsatellite instability and serrated neoplasia pathway. Sessile serrated adenomas/polyps (SSA/Ps) may be the precursor lesions of CRC arising via the serrated neoplasia pathway. This has led to a paradigm shift because all SSA/Ps should be detected and resected during colonoscopy. The ability to accurately detect and resect only those polyps with a malignant potential could result in safer and cost-effective practice. Optimization of the endoscopic classification systems is however needed to implement targeted prevention methods.
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