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  • Title: Organocatalytic asymmetric addition of naphthols and electron-rich phenols to isatin-derived ketimines: highly enantioselective construction of tetrasubstituted stereocenters.
    Author: Montesinos-Magraner M, Vila C, Cantón R, Blay G, Fernández I, Muñoz MC, Pedro JR.
    Journal: Angew Chem Int Ed Engl; 2015 May 18; 54(21):6320-4. PubMed ID: 25845341.
    Abstract:
    A quinine-derived thiourea organocatalyst promoted the highly enantioselective addition of naphthols and activated phenols to ketimines derived from isatins. The reaction afforded chiral 3-amino-2-oxindoles with a quaternary stereocenter in high yields (up to 99%) with excellent enantioselectivity (up to 99% ee). To the best of our knowledge, this transformation is the first highly enantioselective addition of naphthols to ketimines.
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