These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of fruit vinegars on liver damage and oxidative stress in high-fat-fed rats.
    Author: Bouazza A, Bitam A, Amiali M, Bounihi A, Yargui L, Koceir EA.
    Journal: Pharm Biol; 2016; 54(2):260-5. PubMed ID: 25853952.
    Abstract:
    CONTEXT: Vinegar has long been used as a condiment and a traditional medicine worldwide. OBJECTIVE: The current study investigates the antioxidant effect of three types of fruit vinegars (FV) namely pomegranate [Punica granatum L. (Punicaceae)], prickly pear [Opuntia ficus-indica (L.) Mill. (Cactaceae)], and apple [Malus domestica Borkh. (Rosaceae)] vinegars in high-fat diet (HFD)-induced hyperlipidemic Wistar rats. MATERIALS AND METHODS: Fifty male Wistar rats were divided into five groups; HFD (80 cal/d) fed rats were orally dosed with fruit vinegars (7 ml/kg) once daily for 28 weeks. At the end of the experiment, lipid profile, lipid peroxidation products, antioxidant enzymes, and trace elements were assessed in serum. In addition, a liver histopathological study was performed. RESULTS: HFD showed a significant increase (p ≤ 0.05) in lipid profile and TBARS levels when compared with normal control. Daily oral administration of FV normalized various biochemical, metabolic, and histopathological changes. However, pomegranate vinegar exhibited a very significant (p ≤ 0.001) reduction in lipid profile levels (total cholesterol: 165%, triglycerides: 68%, LDL-c: 76%, and atherogenic index: 80%), whereas an increase in antioxidant status (SOD: 7-fold, GPx: 4.81-fold, GRx: 1.66-fold, and TAS: 3.45-fold) when compared with hyperlipidemic control. Histopathological examinations also confirmed the protective effects of pomegranate vinegar against lipid accumulation and the improvement of hepatic lesions. DISCUSSION AND CONCLUSION: The fruit vinegars regulate lipid metabolism and decrease liver damage in high-fat fed rats as shown in this study.
    [Abstract] [Full Text] [Related] [New Search]