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  • Title: Occurrence of pesticide residues and transformation products in different types of dietary supplements.
    Author: Páleníková A, Martínez-Domínguez G, Arrebola FJ, Romero-González R, Hrouzková S, Garrido Frenich A.
    Journal: Food Addit Contam Part A Chem Anal Control Expo Risk Assess; 2015; 32(6):849-56. PubMed ID: 25856415.
    Abstract:
    The purpose of this study was to evaluate the presence of pesticide residues and transformation products in dietary supplement products. Thirty-two samples were analysed to determine 177 pesticides by gas chromatography-tandem mass spectrometry (GC-MS/MS) and 333 pesticides by liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Pesticides were extracted from different kinds of dietary supplements by the use of a modified QuEChERS extraction method. Six samples contained pesticide residues at concentration up to 92.7 µg kg(-1), but only butralin exceeded the maximum residue limits set for raw material. In addition to target compounds, LC-HRMS enables the simultaneous detection of non-target pesticides. In this case, transformation products of pesticides were detected in the analysed samples using HRMS analyser (Exactive-Orbitrap). These compounds were not included in the original method, and they were monitored as post-target compounds, knowing their molecular formula and exact mass. Mass accuracy was always < 2 ppm, corresponding to a maximum mass error. The positive findings endorse the idea that a deeper and continuous investigation of pesticide residues and transformation products in dietary supplement products is necessary in order to guaranty consumer's safety.
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