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  • Title: Direct Aqueous Self-Assembly of an Amphiphilic Diblock Copolymer toward Multistimuli-Responsive Fluorescent Anisotropic Micelles.
    Author: Wu G, Chen SC, Liu CL, Wang YZ.
    Journal: ACS Nano; 2015; 9(4):4649-59. PubMed ID: 25857656.
    Abstract:
    It is extremely important for emerging applications and still enormously challenging to develop multifunctional stimuli-responsive anisotropic polymeric micelles with integration of potentially targeted therapeutic and diagnostic function. Herein, we report a first example of fluorescent anisotropic micelles (FAMs) with Fe(3+), DTT, H2O2, and thermal responsive fluorescence and morphology. FAMs from direct aqueous self-assembly of amphiphilic diblock copolymer showed reversible "switch off/on" of aqua fluorescent emission and controllable structural change by sequential addition of Fe(3+) and DTT. In addition, the FAMs had reversible dual-thermal responsiveness of fluorescence and morphology. This micelle could serve as a promising candidate for all-in-one application of quantitative detecting, imaging, drug delivery, and targeted release.
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