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  • Title: Isoniazid induced convulsions at therapeutic dose in an alcoholic and smoker patient.
    Author: Aiwale AS, Patel UA, Barvaliya MJ, Jha PR, Tripathi C.
    Journal: Curr Drug Saf; 2015; 10(1):94-5. PubMed ID: 25859682.
    Abstract:
    We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis. A case was confirmed by accidental positive de-challenge and rechallenge as well as ruled out other conditions. Use of isoniazid in alcoholic and smoker patient required a caution for prevention of neurological adverse reactions. Pyridoxine should always be prescribed to such patients for the prevention of such adverse reaction.
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