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  • Title: Intravenous streptokinase therapy for acute myocardial infarction in a community hospital: effect on ventricular function and mortality.
    Author: Trask JL, Trask NW, Cushing WJ, Butler HE, Usher BW.
    Journal: J S C Med Assoc; 1989 Nov; 85(11):503-6. PubMed ID: 2586086.
    Abstract:
    Streptokinase can dramatically impact upon management of myocardial infarctions in community hospitals. When given by experienced personnel during the first six hours after onset of symptoms, streptokinase is associated with a high patency rate, improved left ventricular function, and reduced mortality. Careful screening of patients results in a low complication rate with infrequent serious bleeding. Streptokinase should be utilized in those hospitals without cardiac catheterization facilities, but in light of the relatively high incidence of recurrent pain (15.8%), transfer of stable patients to a facility with a catheterization laboratory should be carried out within 24 to 72 hours. As approximately 60% of patients will require PTCA, CABG, or both, diagnostic cardiac catheterization should be considered in all patients unless there are other mitigating factors.
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