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  • Title: Generation and functions of second messengers microdomains.
    Author: Filadi R, Pozzan T.
    Journal: Cell Calcium; 2015 Oct; 58(4):405-14. PubMed ID: 25861743.
    Abstract:
    A compelling example of the mechanisms by which the cells can organize and decipher complex and different functional activities is the convergence of a multitude of stimuli into signalling cascades, involving only few intracellular second messengers. The possibility of restricting these signalling events in distinct microdomains allows a fine and selective tuning of very different tasks. In this review, we will discuss the mechanisms that control the formation and the spatial distribution of Ca(2+) and cAMP microdomains, providing some examples of their functional consequences.
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