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  • Title: [A comparative evaluation of methods for determining the glomerular filtration rate by 169Yb-DTPA clearance].
    Author: Kasatkin IuN, Shliakhto EV, Kaiukov IG, Dolgova IB, Pushkarev AA.
    Journal: Med Radiol (Mosk); 1989 Nov; 34(11):55-8. PubMed ID: 2586263.
    Abstract:
    The authors present the results of comparative analysis of 7 radionuclide clearance methods for the determination of glomerular filtration rate (GFR), based on single administration of 169Yb-DTPC. A reference method was based on the determination of GFR by a curve of a decrease in plasma concentrations with subsequent biexponential analysis on a DVK-2M computer. Methods of the determination of GFR based on 2 blood drawing tests after achieving a uniform distribution of the indicator in its volume of dilution (1) and extracorporal labeling of gamma radiation by a precordial detector (2) showed the highest degree of correlation with the reference method (r = 0.918, p less than 0.001 and r = 0.920, p less than 0.001, respectively). The use of both methods based on a single-chamber model of renal clearance, led to good results, provided the measurements were to start not earlier than 1.5 h after administration of the indicator.
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