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  • Title: [Diagnosis and prenatal diagnosis to a family of hemoglobin variant with α-thalassemia].
    Author: Du L, Wu J, Qin D, Wang J, Luo M, Guo H, Yuan T, Zhang Y, Wang Y, Yin A.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2015 Apr; 32(2):226-8. PubMed ID: 25863092.
    Abstract:
    OBJECTIVE: Diagnosis and prenatal diagnosis to a family of hemoglobin variant with α-thalassemia. METHODS: Whole blood cell analysis, hemoglobin analysis by capillary zone electrophoresis (CZE), Gap-PCR, polymerase chain reaction-reverse dot blot (PCR-RDB) assay and DNA sequencing. RESULTS: Hb Zurich Albisrieden with α°-thalassemia lead to severe anemia. The genotype of fetus is also Hb Zurich Albisrieden with α°-thalassemia. CONCLUSION: Abnormal hemoglobin with α-thalassemia may lead to severe anemia, Prenatal diagnosis of thalassemia has the vital significance for eugenic birth.
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