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  • Title: [Association of VKORC1 gene -1639G/A polymorphism with atrial fibrillation in ethnic Uygurs and Hans from Xinjiang].
    Author: Wu P, Meng S, Zhou X, Xu G, Li J, Zhang Y, Sun L, Xing Q, Sun S, Wang H, Zhou Q, Tang B.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2015 Apr; 32(2):264-8. PubMed ID: 25863101.
    Abstract:
    OBJECTIVE: To assess the association of VKORC1 gene -1639G/A polymorphism with atrial fibrillation (AF) in ethnic Uygurs and Hans from Xinjiang. METHODS: The above polymorphism was detected among 100 Uygur and 102 Han AF patients and 103 Uygur and 111 Han subjects that have no AF with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: A statistically significant difference was detected between the patient and control groups of Uygur origin in terms of genotypic and allelic frequencies (P<0.05). Logistic regression analysis also indicated the -1639G/A polymorphism as an independent risk factor for AF in Uygur population (OR=2.085, 95% CI: 1.067-4.072, P=0.031). No similar statistical difference was found between the patient and control groups of Han origin (P>0.05). CONCLUSION: The -1639G/A polymorphism of VKORC1 gene is associated with AF in the Uygur population but not in Hans.
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