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  • Title: [tRNA as a possible primer for the initiation of reverse transcription of dispersed repeats Alu, B1, B2 and L1].
    Author: Shakhmuradov IA, Kolchanov NA.
    Journal: Mol Biol (Mosk); 1989; 23(4):1130-7. PubMed ID: 2586505.
    Abstract:
    The contextual analysis of the primary structures of 28 various dispersed repeats Alu, B1, B2 and L1 (Kpn1) of primates and rodent genomes has been carried out to search for the regions complementary to the 3'-ends of the known at present tRNA of these organisms. It has been shown that the abundance of the investigated repeats contain the regions revealing marked and statistically non-random complementarity to the 3'-end of at least one of the tRNA considered. Taking into account the retroviruses replication model known from literature these revealed regions are considered as potential primer-binding sites for the initiation of reverse transcription of the mentioned repeats or more long DNA fragments containing them.
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