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  • Title: [Parallel DNA double helices. II. Conformational analysis of regular helices having a second order axis of symmetry].
    Author: Il'icheva IA, Lysov IuP, Chernyĭ AA, Shchelkina AK, Gottikh BP, Florent'ev VL.
    Journal: Mol Biol (Mosk); 1989; 23(4):1145-62. PubMed ID: 2586507.
    Abstract:
    Conformational analysis of double helices of DNA with parallel arranged sugar-phosphate chains connected by twofold symmetry has been performed. Homopolymers poly(dA).poly(dA), poly(dC).poly(dC), poly(dG).poly(dG) and poly(dT).poly(dT) were studied. For each of the homopolymers all variants of H-bond pairing were checked. The maps of closing of sugar-phosphate backbone were previously computed. By the optimization of potential energy the dihedral angles and helix parameters of relatively stable conformations of parallel stranded polynucleotides were calculated. The dependence of conformational energy on the nucleic base character and the base pair type were studied. Two main conformational regions for favourable "parallel" helix of polynucleotides were found. The former of these two regions coincide with the region of typical conformational parameters of B-DNA. On an average the conformational energy of "parallel" DNA is close to the energy of canonic "antiparallel" B-DNA.
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