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  • Title: Dietary soybean peptides containing a low-molecular fraction can lower serum and liver triglyceride levels in rats.
    Author: Tamaru S, Kurayama T, Sakono M, Fukuda N, Nakamori T, Furuta H, Nagata Y, Tanaka K.
    Journal: J Nutr Sci Vitaminol (Tokyo); 2014; 60(6):436-42. PubMed ID: 25866308.
    Abstract:
    We investigated the effects of dietary soybean peptides, particularly low-molecular-weight peptides, on serum and hepatic concentrations of lipids in rats. Soybean protein isolate (SPI) was digested with protease to produce low-molecular-weight peptides (LD) or a mixture of high- and low-molecular-weight peptides (HLD). Rats were fed diets containing 20% casein, SPI, LD or HLD as a nitrogen source, with or without 0.5% cholesterol, for 2 wk. Next, rats were fed cholesterol-free diets containing 0%, 5%, 10%, or 20% LD at the expense of casein for 2 wk. Serum triglyceride levels were the lowest in the LD group, and liver triglyceride levels were significantly lower in rats fed SPI and LD/HLD diets than in those fed casein diets, both in the presence and absence of dietary cholesterol. In addition, dietary LD significantly lowered serum and liver triglyceride levels in a dose-dependent manner. These results suggest that low-molecular-weight soybean peptides have a potent hypotriglyceridemic effect and may be beneficial for improving lipid metabolism.
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