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  • Title: Psoralen derivatives as inhibitors of NF-κB interaction: the critical role of the furan ring.
    Author: Marzaro G, Lampronti I, Borgatti M, Manzini P, Gambari R, Chilin A.
    Journal: Mol Divers; 2015 Aug; 19(3):551-61. PubMed ID: 25869956.
    Abstract:
    Simplified analogues of previously reported NF-κB interaction inhibitors, lacking the furan moiety, were synthesized and evaluated by performing experiments based on electrophoretic mobility shift assay (EMSA). The synthetic modifications led to simpler coumarin derivatives with lower activity allowing to better understand the minimal structural requirement for the binding to NF-κB.
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