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  • Title: [The first cycle of DNA replication in parthenogenetic mouse embryos].
    Author: Severova EL, Samoshkina NA, Dyban AP.
    Journal: Ontogenez; 1989; 20(5):516-24. PubMed ID: 2587012.
    Abstract:
    Dynamics of the first cell cycle in parthenogenetic mouse embryos derived from ethanol-activated eggs was studied using 3H-thymidine. DNA synthesis starts within 5 h and is terminated within 10 h after activation: it lasts ca. 6 h. Changes in the intensity of 3H-thymidine incorporation and in the distribution of radioactive label between haploid and diploid parthenogens were observed. 3H-thymidine was shown to incorporate into pronucleoli of diploid parthenogens and late-labeled heterochromatin blocks were bound in both diploid and haploid pronuclei. The structure of the first cell cycle in parthenogenetic and normal embryos is discussed.
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