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  • Title: Left coronary artery stenosis causing left ventricular dysfunction in two children with supravalvular aortic stenosis.
    Author: Yildiz O, Altin FH, Kaya M, Ozyılmaz I, Guzeltas A, Erek E.
    Journal: World J Pediatr Congenit Heart Surg; 2015 Apr; 6(2):311-6. PubMed ID: 25870356.
    Abstract:
    Congenital supravalvar aortic stenosis (SVAS) is an arteriopathy associated with Williams-Beuren syndrome (WBS) and other isolated elastin gene deletions. Cardiovascular manifestations associated with WBS are characterized by obstructive arterial lesions such as SVAS and pulmonary artery stenosis in addition to bicuspid aortic valve and mitral valve prolapse. However, coronary artery ostial stenosis may be associated with SVAS, and it increases the risk of sudden death and may complicate surgical management. In this report, we present our experience with two patients having SVAS and left coronary artery ostial stenosis with associated left ventricular dysfunction.
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