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  • Title: Asymmetric palladium-catalyzed umpolung cyclization of allylic acetate-aldehyde using formate as a reductant.
    Author: Tsukamoto H, Kawase A, Doi T.
    Journal: Chem Commun (Camb); 2015 May 11; 51(38):8027-30. PubMed ID: 25873404.
    Abstract:
    Palladium/chiral diphosphine-catalyzed umpolung cyclization of allylic acetate-aldehyde using formate as a terminal reductant affords cis-disubstituted pyrrolidine, tetrahydrofuran, and spiro carbocycle in high enantioselectivity. The formate does not cause allylpalladium reduction under the catalysis. The highly stereoselective cyclization would proceed through a cationic η(1)-allylpalladium ligated by diphosphine.
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