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  • Title: Systemic Allergic Contact Dermatitis After Formaldehyde-Containing Influenza Vaccination.
    Author: Kuritzky LA, Pratt M.
    Journal: J Cutan Med Surg; 2015; 19(5):504-6. PubMed ID: 25876644.
    Abstract:
    BACKGROUND: Systemic contact dermatitis occurs when a patient sensitized to an allergen topically is systemically reexposed to the allergen and develops a cutaneous eruption. OBJECTIVE: To report the case of a 48-year-old male who developed explosive dermatitis following injection of a formaldehyde-containing influenza vaccine and was subsequently shown to be strongly positive to formaldehyde and formaldehyde-releasing allergens by patch testing, as well as to review the literature for similar cases. METHODS: A PubMed search was made using the following search terms: systemic contact dermatitis, formaldehyde, influenza, and vaccine. RESULTS: A review of the literature revealed 2 cases of systemic contact dermatitis from formaldehyde derived from aspartame and 1 case from a thimerosal-containing influenza vaccine. No cases caused by formaldehyde in influenza or other vaccines were found. CONCLUSION: This case highlights the importance of considering systemic allergic contact dermatitis in any patient presenting with dermatitis following injection of a formaldehyde-containing vaccine.
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