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  • Title: Modification of cyclophosphamide-induced urotoxicity by buthionine sulfoximine and disulfiram in mice.
    Author: Ishikawa M, Takayanagi Y, Sasaki K.
    Journal: Res Commun Chem Pathol Pharmacol; 1989 Aug; 65(2):265-8. PubMed ID: 2587846.
    Abstract:
    The effect of buthionine sulfoximine (BSO) and disulfiram (DSF) on the urotoxicity induced by cyclophosphamide (CPA) was examined in mice. Pretreatment of mice with BSO (500 mg/kg, i.p.) 5 hr prior to CPA resulted in enhanced urotoxicity of CPA. In contrast, simultaneous administration of DSF (200 mg/kg, p.o.) decreased the urotoxicity of CPA.
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