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  • Title: Membranous nephropathy with monoclonal IgG4 deposits and associated IgG4-related lung disease.
    Author: Omokawa A, Komatsuda A, Hirokawa M, Wakui H.
    Journal: Clin Kidney J; 2014 Oct; 7(5):475-8. PubMed ID: 25878779.
    Abstract:
    A 62-year-old woman was admitted for nephrotic syndrome and lung tumor. A renal biopsy showed membranous features of the glomeruli. Immunofluorescence studies revealed granular IgG4-κ deposits along with the glomerular basement membrane. Electron microscopy revealed granular electron-dense deposits. Further study denied multiple myeloma. Light microscopy of the resected lung tumor revealed IgG4-related lung disease with no malignancy. Steroid therapy induced a remission of the nephrotic syndrome, with no recurrence of the lung tumor. We consider that this is the first case of a proliferative glomerulonephritis with monoclonal IgG deposits of IgG4 subclass, and a rare concurrence with IgG4-related disease.
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