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  • Title: Conformal radiotherapy for locally advanced juvenile nasopharyngeal angio-fibroma.
    Author: Mallick S, Benson R, Bhasker S, Mohanti BK.
    Journal: J Cancer Res Ther; 2015; 11(1):73-7. PubMed ID: 25879340.
    Abstract:
    PURPOSE: To assess the efficacy of radiation in the treatment of juvenile nasopharyngeal angiofibroma (JNA). MATERIALS AND METHODS: Data were retrieved for JNA treated with radiotherapy from 1987-2012. The demographics, treatment and outcome data were recorded in predesigned proforma. RESULTS: Data of 32 patients were retrieved. Median age was 17 years (range: 12-33 years). All patients received radiation because of refractory, residual or unresectable locally advanced disease. All patients were planned with a three-dimensional conformal technique (3DCRT). The median radiation dose was 30 Gray (range: 30-45 Gray). Median follow-up was 129 months (range: 1-276 months). At the last follow-up, 13 patients were found to have a radiological complete response. Two patients progressed 38 and 43 months after completion of treatment and opted for alternative treatment. One patient developed squamous cell carcinoma of the nasal ale 15 years after radiation. CONCLUSION: Conformal radiotherapy shows promise as an alternative treatment approach for locally advanced JNA and confers long-term disease control with minimal toxicity.
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