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  • Title: [Evaluation of obzidan efficacy in patients with unstable stenocardia].
    Author: Gvatua NA, SHumakov VA, Tashchuk VK, Malinovskaia IE, Pliska AI.
    Journal: Ter Arkh; 1989; 61(8):21-4. PubMed ID: 2588162.
    Abstract:
    Altogether 75 patients (males aged 31 to 67 years) with unstable angina pectoris were subjected to transcutaneous pacing to measure the coronary reserve level before and after administration of obsidan (propranolol) in a dose of 40 mg. The area and depth of ischemia were found to be noticeably decreased, which was appraised according to 35 precordial leads on the ECG regardless of the unchanged "double product". It is concluded that not only the reduction of the heart rate and afterload but also their effect on the functional factors of angina pectoris are implicated in the mechanism of the anti-ischemic action of the beta-blockers.
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