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  • Title: Neutrophil-lymphocyte ratio is associated with arterial stiffness in postmenopausal women with osteoporosis.
    Author: Yu XY, Li XS, Li Y, Liu T, Wang RT.
    Journal: Arch Gerontol Geriatr; 2015; 61(1):76-80. PubMed ID: 25882272.
    Abstract:
    OBJECTIVE: Systemic inflammation may be a common mechanism for the development of osteoporosis (OP) and atherosclerosis. Elevated arterial stiffness is an index of subclinical atherosclerosis. Recent studies found that neutrophil/lymphocyte ratio (NLR), is a useful marker of cardiovascular disease and a more powerful predictor than any other leukocyte subtypes. However, little research has been conducted to investigate the relationship between NLR and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). METHODS: In this cross-sectional study, we examined the relationship between NLR and baPWV in 512 subjects. RESULTS: Compared to the control subjects, NLR and baPWV increased in patients with OP. Partial correlation analysis revealed that there was a significant correlation between NLR and baPWV after adjusting for confounding factors in OP. Multivariate linear regression analysis showed that NLR was a significant factor for increased baPWV in patients with OP (β=0.249, p<0.001). However, there was no association between NLR and baPWV in control subjects. CONCLUSION: NLR and baPWV are elevated in OP. Moreover, NLR is independently associated with baPWV. Further studies are warranted to investigate whether anti-inflammatory treatment could improve arterial stiffness in postmenopausal women with OP.
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