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  • Title: [Klinefelter's syndrome associated with primary mediastinal germinal cell tumor].
    Author: Nielsen HL, Frandsen F.
    Journal: Ugeskr Laeger; 1989 Oct 30; 151(44):2897-8. PubMed ID: 2588377.
    Abstract:
    A case of a man aged 25 year with Klinefelter's syndrome (KS) associated with a primary malignant germinal cell tumour is presented. Echocardiography was of assistance in the diagnosis as a tumour behind the heart was demonstrated. If patients with KS develop cardiopulmonary symptoms, referral for x-ray of the thorax is recommended. If there is enlargement of the heart or increase in width of the mediastinum, echocardiography should be performed. This case history emphasizes further that a negative cytological test does not disprove malignancy.
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