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  • Title: [Use of a noninvasive parameter of early diastolic ventricle function for the detection of graft rejection following heart transplantation].
    Author: Park JW, Urbanczyk M, Schüler S, Warnecke H, Hetzer R, Fleck E.
    Journal: Z Kardiol; 1989 Oct; 78(10):668-73. PubMed ID: 2588755.
    Abstract:
    Since changes in left ventricular early diastolic time intervals can be expected as one of the first detectable functional alterations indicating acute rejection in cardiac transplant patients, time-constant Te, a parameter derived from digitized M-mode echocardiogram, was proved as a marker of acute rejection. Echo results of 30 transplant patients (5-63 yrs) were correlated with myocardial biopsy results (48 rejection negative, 16 rejection positive) of the same day. In transplant patients the M-mode echo parameter Te is prolonged even in phases without rejection (79.0 +/- 12.5 ms vs 64.0 +/- 7.9 ms of healthy controls; p less than 0.0001). Te of transplant patients during rejection were significantly longer than Te of patients without rejection (97.8 +/- 17.9 ms vs 79.0 +/- 12.5 ms; p less than 0.0001). Individual courses demonstrate that rejection is associated with further prolongation of Te and that Te returns to individual basic value in response to treatment. So, Te may prove as a useful noninvasive marker of acute cardiac rejection.
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