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  • Title: Role of digital tomosynthesis and dual energy subtraction digital radiography in detecting pulmonary nodules.
    Author: Kumar SG, Garg MK, Khandelwal N, Gupta P, Gupta D, Aggarwal AN, Bansal SC.
    Journal: Eur J Radiol; 2015 Jul; 84(7):1383-91. PubMed ID: 25892052.
    Abstract:
    OBJECTIVE: Digital tomosynthesis (DT) and dual-energy subtraction digital radiography (DES-DR) are known to perform better than conventional radiography in the detection of pulmonary nodules. Yet the comparative diagnostic performances of DT, DES-DR and digital radiography (DR) is not known. The present study compares the diagnostic performances of DT, DES-DR and DR in detecting pulmonary nodules. SUBJECTS AND METHODS: The institutional Review Board approved the study and informed written consent was obtained. Fifty-five patients (30 with pulmonary nodules, 25 with non-nodular focal chest pathology) were included in the study. DT and DES-DR were performed within 14 days of MDCT. Composite images acquired at high kVp as part of DES-DR were used as DR images. Images were analyzed for presence of nodules and calcification in nodules. Interpretations were assigned confidence levels from 1 to 5 according to Five-Point rating scale. Areas under the receiver operating characteristic curves were compared using Z test. RESULTS: A total of 110 (88 non-calcified, 22 calcified) nodules were identified on MDCT. For detection of nodules, DR showed cumulative sensitivity and specificity of 25.45% and 67.97%, respectively. DT showed a cumulative sensitivity and specificity of 60.9% and 85.07%, respectively. The performance was significantly better than DR (p<0.003). DES-DR showed sensitivity and specificity of 27.75% and 82.64%, not statistically different from those of DR (p-0.92). In detection of calcification, there was no statistically significant difference between DT, DES-DR and DR. CONCLUSIONS: DT performs significantly better than DES-DR and DR at the cost of moderate increase in radiation dose.
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