These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Modular Synthesis of Constrained Ethyl (cEt) Purine and Pyrimidine Nucleosides.
    Author: Blade H, Bradley D, Diorazio L, Evans T, Hayter BR, Howell GP.
    Journal: J Org Chem; 2015 May 15; 80(10):5337-43. PubMed ID: 25894018.
    Abstract:
    A modular and scalable approach to pyrimidine- and purine-containing constrained ethyl (cEt) nucleosides is demonstrated. Minimizing stereochemical adjustments and protecting group manipulations, diacetone glucose is converted to two representative cEt nucleosides via a functionalized, common intermediate. The retrosynthetic approach to this complex class of drug precursors offers clear benefits over existing routes based on step count and efficiency.
    [Abstract] [Full Text] [Related] [New Search]