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  • Title: Effects of antibiotic treatment on the lactobacillus composition of vaginal microbiota.
    Author: Melkumyan AR, Priputnevich TV, Ankirskaya AS, Murav'eva VV, Lubasovskaya LA.
    Journal: Bull Exp Biol Med; 2015 Apr; 158(6):766-8. PubMed ID: 25894774.
    Abstract:
    We analyzed sensitivity of 123 vaginal lactobacillus strains to antibacterial substances. All lactobacillus strains were sensitive to ampicillin, cefazolin, cefotaxime, and vancomycin, and insensitive to metronidazole, trimethoprim/sulfamethoxazole, and levofloxacin. Lactobacillus strains demonstrated different sensitivity to gentamycin, clindamycin, erythromycin, ciprofloxacin, and tetracycline. The phenomenon of preferential selective influence of antibacterial drugs on the composition of lactobacilli of the vaginal microbiota, in which some lactobacilli survive as part of the vaginal microbiota and have a selective advantage over other types of lactobacilli, should be taken into account during treatment of vaginal infections and dysbiosis.
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