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  • Title: Effect of anthracycline antibiotics on the reconstituted mitochondrial tricarboxylate carrier.
    Author: Stipani I, Capalbo MI, Zara V.
    Journal: Biochem Biophys Res Commun; 1989 Nov 15; 164(3):1281-7. PubMed ID: 2590202.
    Abstract:
    The effect of anthracycline antibiotics on the activity of the partially purified and reconstituted tricarboxylate carrier system of the rat liver mitochondria was studied. It was found that the citrate/citrate exchange activity is inhibited by Br-daunomycin and with less potency by doxorubicin, daunomycin, epirubicin and idarubicin. The inhibition of the citrate transport activity is concentration and time-dependent. Cardiolipin protects against the inhibition by Br-daunomycin and the reconstituted citrate transport activity depends upon the ratio of cardiolipin/Br-daunomycin.
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