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  • Title: Genetic variants in interleukin 7 receptor α chain (IL-7Ra) are associated with multiple sclerosis risk and disability progression in Central European Slovak population.
    Author: Čierny D, Hányšová S, Michalik J, Kantorová E, Kurča E, Škereňová M, Lehotský J.
    Journal: J Neuroimmunol; 2015 May 15; 282():80-4. PubMed ID: 25903732.
    Abstract:
    In this study, we determined the association between rs6897932 in interleukin 7 receptor α (IL7Ra) gene and the risk and disability progression of multiple sclerosis (MS) in 270 MS patients and 303 controls. We found allele C to be associated with the risk of MS and minor allele T to be protective against MS development. Moreover, we revealed for the first time that rs6897932 in IL7Ra gene is associated with the progression of MS, evaluated by MSSS scores. The minor allele T and genotype TT are protective against a rapid disability progression in MS in the Central European Slovak population.
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