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  • Title: Intravenous immunoglobulin may reduce relapse frequency in neuromyelitis optica.
    Author: Viswanathan S, Wong AH, Quek AM, Yuki N.
    Journal: J Neuroimmunol; 2015 May 15; 282():92-6. PubMed ID: 25903734.
    Abstract:
    OBJECTIVES: To evaluate the use of intravenous immunoglobulin (IVIG) in preventing relapses in patients with neuromyelitis optica (NMO) and its spectrum disorders (NMOSDs). METHODS: Six NMO/NMOSD patients who were treated with IVIG induction dose followed by 2- to 3- monthly infusions were retrospectively identified. Annualized relapse rates (ARR) and Expanded Disability Status Scale (EDSS) pre- and post-IVIG were recorded. RESULTS: Median number of relapses and median ARR significantly reduced from 8.0 to 1.0 and 0.75 to 0.15 (p<0.05) respectively. Median EDSS of 6.5 remained the same. Median duration of treatment was 4.0 years. CONCLUSION: IVIG may be used to reduce the relapse frequency in patients with NMO/NMOSD.
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