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  • Title: PH oscillations in cell suspensions of Dictyostelium discoideum: their relation to cyclic-amp signals.
    Author: Malchow D, Nanjundiah V, Gerisch G.
    Journal: J Cell Sci; 1978 Apr; 30():319-30. PubMed ID: 25904.
    Abstract:
    Cells of Dictyostelium discoideum known to release cyclic AMP (cAMP) rhythmically in the form of pulses, change with the same period of about 8 min the pH of their medium. The pH is used here as an indicator to investigate the effect of externally added cAMP pulses on the oscillations. Both a temporary increase in amplitude and a permanent phase shift can be induced. The phase-response curve indicates that the period can be increased and decreased by rhythmic stimulation with cAMP pulses.
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