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  • Title: Synthesis and cytotoxicity of longistylin C derivatives.
    Author: Shan Y, Hong T, Wang YF, Zhang NL, Yu B, Lu Y, Qiu SX.
    Journal: Chin J Nat Med; 2015 Apr; 13(4):311-5. PubMed ID: 25908631.
    Abstract:
    The present study was designed to identify potent anti-tumor compounds from a series of new longistylin C derivatives. Ten longistylin C derivatives were synthesized and their structures were confirmed by (1)H NMR, MS, and elemental analyses. Their cytotoxicity in vitro against three human cancer cell lines (A549, HepG2, and MCF-7) were evaluated by the MTT assay. Among these compounds, DT-6 and DT-9 displayed much better cytotoxicity against A549, HepG2, and MCF-7 cells, DT-1 exhibited selective cytotoxicity against HepG2, and the structure-activity relationships were investigated. In conclusion, Compounds DT-6 and DT-9 may serve as potential lead compounds for the discovery of new anti-cancer drugs.
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