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  • Title: Sedation or general anesthesia for patients undergoing transcatheter aortic valve implantation--does it affect outcome? An observational single-center study.
    Author: Goren O, Finkelstein A, Gluch A, Sheinberg N, Dery E, Matot I.
    Journal: J Clin Anesth; 2015 Aug; 27(5):385-90. PubMed ID: 25912486.
    Abstract:
    UNLABELLED: Aortic stenosis is one of the most common valvular lesions. Nowadays, a new treatment is emerging: the transcatheter aortic valve implantation (TAVI). It is considered a suitable alternative for the surgical approach in selected high-risk patients. This procedure may be performed under sedation (SED) or under general anesthesia (GEA). STUDY OBJECTIVE: Assess the feasibility and safety of TAVI under sedation. DESIGN: Observational study. SETTING: Single-center study conducted between the years 2009 and 2012. PATIENTS: A total of 204 American Society of Anesthesiologists physical status 3 to 4 patients who underwent TAVI in the study period and for whom complete data were obtained were included. Demographic and periprocedural data were acquired from the patients' files. The patients were divided into SED and GEA groups. INTERVENTIONS: The study was not an interventional study. MEASUREMENTS: The study did not include measurements. MAIN RESULTS: The 2 groups had similar demographic characteristics and echocardiographic parameters. The rate of conversion from SED to GEA was 4.6%. The SED group received significantly less catecholamines and intravenous fluids during the procedure. The total procedural time was significantly shorter for the SED group. There was a trend toward more postprocedural pulmonary complications in the GEA group. In-hospital mortality and total length of stay were similar between the groups. CONCLUSIONS: The results of the current study, which included a relatively large number of patients, suggest that both anesthetic modalities are safe for patients undergoing TAVI. The anesthesiologist should thus tailor the anesthetic approach to the patient, taking into account the team's experience as well as the hemodynamic status of the patient. With growing experience, our team recommends performing TAVI under SED and in selected cases under GEA.
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