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  • Title: Enantioselective Syntheses of Heteroyohimbine Natural Products: A Unified Approach through Cooperative Catalysis.
    Author: Younai A, Zeng BS, Meltzer HY, Scheidt KA.
    Journal: Angew Chem Int Ed Engl; 2015 Jun 01; 54(23):6900-4. PubMed ID: 25914164.
    Abstract:
    Alstonine and serpentine are pentacyclic indoloquinolizidine alkaloids (referred to as "anhydronium bases") containing three contiguous stereocenters. Each possesses interesting biological activity, with alstonine being the major component of a plant-based remedy to treat psychosis and other nervous system disorders. This work describes the enantioselective total syntheses of these natural products with a cooperative hydrogen bonding/enamine-catalyzed Michael addition as the key step.
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