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  • Title: Self-Assembly of Disorazole C1 through a One-Pot Alkyne Metathesis Homodimerization Strategy.
    Author: Ralston KJ, Ramstadius HC, Brewster RC, Niblock HS, Hulme AN.
    Journal: Angew Chem Int Ed Engl; 2015 Jun 08; 54(24):7086-90. PubMed ID: 25926364.
    Abstract:
    Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.
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