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  • Title: Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase.
    Author: Awakawa T, Crüsemann M, Munguia J, Ziemert N, Nizet V, Fenical W, Moore BS.
    Journal: Chembiochem; 2015 Jul 06; 16(10):1443-7. PubMed ID: 25930739.
    Abstract:
    Salinipyrones and pacificanones are structurally related polyketides from Salinispora pacifica CNS-237 that are proposed to arise from the same modular polyketide synthase (PKS) assembly line. Genome sequencing revealed a large macrolide PKS gene cluster that codes for the biosynthesis of rosamicin A and a series of new macrolide antibiotics. Mutagenesis experiments unexpectedly correlated salinipyrone and pacificanone biosynthesis to the rosamicin octamodule Spr PKS. Remarkably, this bifurcated polyketide pathway illuminates a series of enzymatic domain- and module-skipping reactions that give rise to natural polyketide product diversity. Our findings enlarge the growing knowledge of polyketide biochemistry and illuminate potential challenges in PKS bioengineering.
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