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  • Title: [Functional state of blood platelets in arterial hypertension and the changes in serotonin-containing cellular granules].
    Author: Mezhlumian AG, Vikhert OA, Gabbasov ZA, Maĭsov NI, Gavrilov IIu, KrotovSN, Arabidze GG, Popov EG.
    Journal: Kardiologiia; 1989 Sep; 29(9):13-8. PubMed ID: 2593466.
    Abstract:
    The study was undertaken to examine the status of the granular apparatus and platelet aggregability in 9 healthy donors and 18 patients with arterial hypertension (AH), including 14 with essential hypertension (EH) and 4 with symptomatic forms of AH. Among the patients, a group of 8 EH patients was singled out, who had, compared with normal, reduced relative volumes of electron dense platelet granules (from 17.9 +/- 2.0 to 5.3 +/- 0.6%). The group also showed lower platelet serotonin levels (from 67.3 +/- 5.3 to 17.6 +/- 3.7 ng per 10(8) cells; p less than 0.001) and a 2-fold decrease in the transport factor of acridine orange across the cytoplasmic and granular membranes as compared to normal. A positive correlation was established between the amounts of cellular serotonin and the relative volume of platelet granules (r = 0.850; p less than 0.001).
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