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  • Title: Action of mycosubtilin on erythrocytes and artificial membranes.
    Author: Besson F, Quentin MJ, Michel G.
    Journal: Microbios; 1989; 59(240-241):137-43. PubMed ID: 2593867.
    Abstract:
    Mycosubtilin has a strong lytic action upon erythrocytes. The haemolytic effect of the antibiotic is inhibited by free cholesterol as well as cholesterol included in liposomes of phosphatidylcholine-cholesterol. The antibiotic binding on artificial membranes was studied with radioactive bilayer vesicles of dipalmitoylphosphatidylcholine (DPPC), and DPPC-cholesterol:mycosubtilin destroyed both kinds of vesicles. The inhibition of the haemolytic effect of mycosubtilin by liposomes is a result of an interaction which diminishes the concentration of free cholesterol.
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