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  • Title: Eunicellin-Based Diterpenoids, Hirsutalins S-V, from the Formosan Soft Coral Cladiella hirsuta.
    Author: Huang TZ, Chen BW, Huang CY, Hwang TL, Uvarani C, Dai CF, Sung PJ, Su JH, Sheu JH.
    Journal: Mar Drugs; 2015 Apr 30; 13(5):2757-69. PubMed ID: 25942094.
    Abstract:
    Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/ CB-induced human neutrophils.
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