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  • Title: Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus.
    Author: Sparzak B, Krauze-Baranowska M, Kawiak A, Sowiński P.
    Journal: Molecules; 2015 Apr 30; 20(5):7915-24. PubMed ID: 25942372.
    Abstract:
    A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7'-oxocubebin dimethylether (1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-bis(methoxymethyl)butan-1-on). The non-transformed root cultures of P. amarus showed to be a selective source of this compound. The lignan revealed strong cytotoxic activity against HeLa cell line with an IC50 value of 3.8 µg/mL.
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