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  • Title: Characterization of an Enterococcus gallinarum Isolate Carrying a Dual vanA and vanB Cassette.
    Author: Eshaghi A, Shahinas D, Li A, Kariyawasam R, Banh P, Desjardins M, Melano RG, Patel SN.
    Journal: J Clin Microbiol; 2015 Jul; 53(7):2225-9. PubMed ID: 25948610.
    Abstract:
    The ability of vancomycin resistance determinants to be horizontally transferred within enterococci species is a concern. Identification and characterization of vancomycin-resistant enterococci (VRE) in a clinical isolate have a significant impact on infection control practices. In this study, we describe a clinical isolate of Enterococcus gallinarum exhibiting high-level resistance to vancomycin and teicoplanin. The genetic characterization of this isolate showed the presence of vanA and vanB genes in addition to the naturally carried vanC gene. vanA was identified on pA6981, a 35,608-bp circular plasmid with significant homology to plasmid pS177. The vanB operon was integrated into the bacterial chromosome and showed a high level of homology to previously reported Tn1549 and Tn5382. To the best of our knowledge, this is the first report of E. gallinarum carrying both vanA and vanB operons, indicating the importance of identifying the vancomycin resistance mechanism in non-E. faecium and non-E. faecalis enterococcal species.
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