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  • Title: Dexamethasone suppression test in positive and negative schizophrenia.
    Author: Altamura C, Guercetti G, Percudani M.
    Journal: Psychiatry Res; 1989 Oct; 30(1):69-75. PubMed ID: 2594873.
    Abstract:
    Fifty-four inpatients with a DSM-III diagnosis of schizophrenia were studied. Patients were divided into positive and negative subtypes of schizophrenia according to Andreasen's criteria. Blood samples were obtained from all patients for 2 consecutive days to determine plasma cortisol concentrations before and after a single administration (1 mg, p.o.) of dexamethasone at 11 p.m. The results revealed a significant increase in plasma cortisol levels in schizophrenic patients, with 40% of the patients being nonsuppressors on the dexamethasone suppression test. A higher percentage (62.5%) of patients with the negative form of schizophrenia were nonsuppressors.
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