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  • Title: The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides.
    Author: Yang WL, Liu YZ, Luo S, Yu X, Fossey JS, Deng WP.
    Journal: Chem Commun (Camb); 2015 Jun 04; 51(44):9212-5. PubMed ID: 25952504.
    Abstract:
    A highly efficient asymmetric 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides catalyzed by a novel chiral N,O-ligand/Cu(OAc)2 system is reported, affording dispiropyrrolidine derivatives with spiro quaternary stereogenic centers in good to excellent yields (up to 90%), excellent levels of diastereoselectivities (>20 : 1 dr) and enantioselectivities (up to 97% ee).
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