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  • Title: Absorption of water and solute from glucose-electrolyte solutions in the human jejunum: effect of citrate or betaine.
    Author: Leiper JB, Maughan RJ.
    Journal: Scand J Gastroenterol; 1989 Nov; 24(9):1089-94. PubMed ID: 2595270.
    Abstract:
    The inclusion in oral rehydration solutions of solutes that are actively co-transported with sodium has been suggested as a means of increasing the effect of glucose on water absorption by the small intestine. Using a modified perfusion system we have examined water and solute absorption in the normal human intestine from two effervescent glucose-electrolyte solutions, containing either citrate or betaine hydrochloride, and compared the absorption rates with those from a commonly used bicarbonate-containing oral rehydration solution. Absorption of citrate (355 +/- 87 mumol/cm/h) and betaine (313 +/- 125 mumol/cm/h) occurred from the respective solutions. The inclusion of 46 mmol/l citrate or 36 mmol/l betaine in effervescent oral rehydration solutions had no effect on water or solute absorption.
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