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  • Title: Role of PAF in ischemia-reperfusion injury in the rat stomach.
    Author: Iwai A, Itoh M, Yokoyama Y, Yasue N, Miyamoto T, Joh T, Matsusako K, Endoh K, Kawai T, Takeuchi T.
    Journal: Scand J Gastroenterol Suppl; 1989; 162():63-6. PubMed ID: 2595310.
    Abstract:
    Ischemia-reperfusion induced extensive gastric mucosal injury and an increase in chemiluminescence activity of neutrophils obtained from the portal vein in hemorrhagic shock rats. CV-3988, a selective antagonist of platelet activating factor (PAF), significantly reduced the gross and histologic gastric damage, and the increase in chemiluminescence activity of neutrophils. These results suggest that PAF generated on hypoxia might stimulate oxygen radical production by neutrophils, resulting in the occurrence of gastric injury in hemorrhagic shock rats.
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